![]() Out, it can be diagnosed as a specific disease: focal and segmental Only when thereĪre clinical findings of glomerulopathy and other glomerulonephritis are ruled Is a relatively frequent lesion produced by multiple causes. The focal and segmental glomerulosclerosis PAS and silver stains because contains a different collagen, predominantly type Tuft proliferates from the capsule and is negative, or weakly positive, with The fibrous tissue that surrounds the sclerosed capillary Material of the capillary tuft is seen more intensively stained with PAS (left)Īnd methenamine-silver stains (right) because sclerosed glomeruli contain abundant Globally sclerosed glomerulus with ischemic origin of the injury. ![]() Or remaining fragments of tuft fibrinoid necrosis, or immune deposits in notĬompletely sclerosed tufts, which can orient to a glomerulonephritis as cause Sometimes can be demonstrated rests of a crescent, Originated glomerular sclerosis have a characteristic pattern of retractionĪnd collapse of capillary tuft (PAS-positive) surrounded by fibrotic tissue When this happens can be impossible to determine the cause of the damage. ![]() The glomeruli can display global sclerosis In the evaluation of the glomerular alterations is to determine the extension Glomeruli) or diffuse (in all or almost all the glomeruli), and segmental (onlyĪ part of the glomerulus) or global (the entire glomerulus). Glomerular changes can be focal (only in some To adequately classify the renal alterations. We need clinical data, immunofluorescence, and, in many cases, electron microscopy Most of morphologic patterns of renal injuryĭo not correspond with only one disease. In the task of determining the primary site of injury. More or less characteristic histopathologic features that guide the pathologist Which will affect the remaining histologic structures. Glomeruli, interstitium, and tubules or the injury can begin in glomeruli, ![]() We can have a vascular injury that when advancing the process will finish affecting Injury is not an easy task: injuries in a part of nephron affect the other compartments. Glomeruli, interstitium, tubules or vessels. That prevents us missing a lesion in any of the four histologic compartments: When evaluating a renal biopsy we must follow a systematic process Histologic patterns of glomerular changes ![]()
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